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M9550097.TXT
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1995-03-04
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Document 0097
DOCN M9550097
TI Hemostatic disorders in feline immunodeficiency virus-seropositive cats.
DT 9505
AU Hart SW; Nolte I; Clinic of Small Animals, Hanover School of Veterinary
Medicine,; Germany.
SO J Vet Intern Med. 1994 Sep-Oct;8(5):355-62. Unique Identifier : AIDSLINE
MED/95138904
AB The hemostatic function of 40 feline immunodeficiency virus (FIV)
seropositive and 8 FIV and feline leukemia virus (FeLV) seropositive
cats was evaluated and compared with reference values from 30 clinically
healthy cats. The FIV-positive cats were divided into 3 groups: group I
included asymptomatic carriers; group II comprised sick FIV-infected
cats with illnesses not likely to influence the hemostatic system; and
group III included FIV-positive cats with diseases potentially
associated with coagulopathies. Platelet counts in FIV/FeLV-infected
cats were significantly lower than in healthy cats (P < .003), whereas
the differences in the 3 groups of FIV-positive cats were variable
(group I, P = .009; II, P = .05; III, P = .09). Thrombocytopenia (<
145,000 platelets/microL) was present in 4 FIV-positive and 3
FIV/FeLV-positive cats. Platelet aggregation induced by collagen (0.5
and 0.25 micrograms/mL), adenosine diphosphate (ADP) (1 and 0.6
mumol/L), and thrombin (0.4 and 0.25 IU/mL) was not significantly
different from that of healthy cats. The plasma coagulation system was
evaluated by measuring one-stage prothrombin time (OSPT), activated
partial thromboplastin time (APTT), thrombin time, fibrinogen
concentration, coagulation factor assays, fibrinogen and fibrin
degradation products (FDP), and plasma exchange test. The OSPT was
similar in FIV-seropositive cats and in the healthy control group. Cats
with FIV infection, however, had markedly shorter clotting times than
healthy cats when using a modified test system (P < .05).(ABSTRACT
TRUNCATED AT 250 WORDS)
DE Animal Blood Coagulation Disorders/IMMUNOLOGY/*VETERINARY Cat
Diseases/*IMMUNOLOGY/VIROLOGY Cats Factor VIII/ANALYSIS Feline
Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Female
Fibrinogen/ANALYSIS Hemostasis Immunodeficiency Virus,
Feline/IMMUNOLOGY Leukemia Virus, Feline/IMMUNOLOGY Male
Thrombocytopenia/DIAGNOSIS/VETERINARY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).